名称 |
Human TGF-beta 1 / TGFB1 Protein/重组人TGFB1 蛋白 |
规格 |
20ug |
编号 |
CZDB-013 |
价格 |
询价 |
中文名 |
Human TGF-beta 1 / TGFB1 Protein/重组人TGFB1 蛋白 |
分子别称 |
TGFB1 |
分子种属 |
Human |
表达标签 |
His,S |
表达宿主 |
E. coli |
浓度 |
> 95 % as determined by SDS-PAGE |
缓冲液 |
Lyophilized from sterile PBS, pH 7.4 |
存储条件 |
-70°C,应避免反复冻融。 |
基本描述 |
TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. TGF-beta 1 positively and negatively regulates many other growth factors. It inhibits the secretion and activity of many other cytokines including interferon-γ, tumor necrosis factor-alpha and various interleukins. It can also decrease the expression levels of cytokine receptors. Meanwhile, TGF-beta 1 also increases the expression of certain cytokines in T cells and promotes their proliferation, particularly if the cells are immature. TGF-beta 1 also inhibits proliferation and stimulates apoptosis of B cells, and plays a role in controlling the expression of antibody, transferrin and MHC class II proteins on immature and mature B cells. As for myeloid cells, TGF-beta 1can inhibit their proliferation and prevent their production of reactive oxygen and nitrogen intermediates. However, as with other cell types, TGF-beta 1 also has the opposite effect on cells of myeloid origin. TGF-beta 1 is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Once cells lose their sensitivity to TGF-beta1-mediated growth inhibition, autocrine TGF-beta signaling can promote tumorigenesis. Elevated levels of TGF-beta1 are often observed in advanced carcinomas, and have been correlated with increased tumor invasiveness and disease progression. |