名称

Mouse gp130 / IL6ST / CD130 Protein/重组小鼠 gp130

规格

20ug

编号

CZDB-001

价格

询价

中文名

重组小鼠 gp130 / IL6ST / CD130 蛋白

分子别称

Ac1055, Gp130, Il-6rb

分子种属

Mouse

表达标签

His，S

表达宿主

E. coli

浓度

> 95 % as determined by SDS-PAGE

缓冲液

Lyophilized from sterile PBS, pH 7.4

存储条件

-70°C，应避免反复冻融。

基本描述

Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD130/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. CD130/gp130 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD130/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.